Protein trafficking is a fundamental cellular process that ensures efficient sorting, modification, and delivery of proteins to their correct subcellular destinations. At its core, this process ...
Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients. These substances are first transported as cargo to the initial sorting compartment ...
RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...
When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, ...
When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, ...
The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a ...
Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...
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