Scientists are closing in on a deceptively simple idea with radical implications: that a single protein signal in the blood ...

Heart failure occurs when the heart can no longer pump blood efficiently to meet the body’s needs. Beyond weakened muscle cells, new research highlights the hidden role of fibroblasts—supporting cells ...

Background: Excessive fibrosis and chronic inflammation are key contributors to adverse cardiac remodeling and dysfunction following myocardial infarction (MI). The interaction between fibroblasts, ...

SSc and SLE are chronic autoimmune diseases with distinct and overlapping characteristics, including fibrosis in SSc and systemic inflammation in SLE. RNA sequencing identified differentially ...

Chronic pain, sexual dysfunction and incontinence can all stem from problems with your pelvic floor — and many men don’t even know they have one. By Danielle Friedman In his early 30s, Chad Woodard ...

Fibroblast activation protein (FAP) is a serine protease, the expression of which increases with pathogenic fibroblasts in the fibrotic liver during metabolic dysfunction-associated steatohepatitis ...

Fibroblast growth factor 21 (FGF21) analogs significantly improve fibrosis and resolve metabolic dysfunction-associated steatohepatitis (MASH) without progression, showing promise for non-cirrhotic ...

Background Autosomal dominant Huntington’s disease (HD) caused by expansion of CAG triplet in gene for protein huntingtin is characterized by chorea, neuropsychiatric symptoms, and progressive ...