Dr Maitta research interests span both clinical/ translational medicine and basic science. His work was the first to report using a murine model the importance of α-synuclein in development/ ...

At the Government Kilpauk Medical College (KMC) Hospital, its ‘Red Alert OBG’, a multidisciplinary rapid response team for maternal care, enabled the early diagnosis and prompt treatment of a ...

Based on these postmarketing reports, the FDA is evaluating the need for further regulatory action. The Food and Drug Administration (FDA) is investigating the risk of developing neutralizing ...

Nov 21 (Reuters) - The U.S. Food and Drug Administration said on Friday it is investigating the death of a child who developed harmful antibodies after receiving Takeda Pharmaceuticals' (4502.T), ...

For reference, ADAMTS13 is a key regulator of blood clotting, preventing excessive clot formation in normal circulation. Its primary function is to cleave vWF, a large protein that helps platelets ...

The FDA has opened an investigation into Takeda’s recombinant protein med Adzynma following the reported death of a pediatric patient who received the drug. The probe comes as the regulator says it ...

The FDA said it has received postmarketing reports of neutralizing antibodies to ADAMTS13, including one death, in patients with congenital thrombotic thrombocytopenic purpura (cTTP) who were treated ...

A new mum who was diagnosed with a rare condition after spotting a "weird" bruise during pregnancy has revealed just how terrifyingly close she was to death. Rebekah, 27, was 28 weeks into her ...

These causes of TMA must be distinguished from TTP, which results from a severe deficiency of ADAMTS13 and is the most common cause of TMA among adults without cancer. The importance of this ...

ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, 13), primarily synthesized in hepatic stellate and endothelial cells, plays a pivotal role in regulation of hemostasis ...

Hepatic platelet accumulation in PA-ILI was confirmed in both patients and mice. Deficiency of ADAMTS13 plays a critical role in platelet accumulation in PA-ILI, suggesting that ADAMTS13 could be a ...

Pyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced liver injury ...