POLG mitochondrial disease is a rare genetic disorder caused by mutations in the POLG gene, which is responsible for ...

Researchers from Pretzel Therapeutics Inc. and the University of Gothenburg have published new insights on how mutations in the POLG gene affect its functionality and are tied to PolG diseases. They ...

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective POLG enzyme, critical for mitochondrial DNA replication. The compound has ...

WALTHAM, Mass., April 09, 2025--Pretzel Therapeutics, a leader in harnessing cellular energetics to develop novel treatments for a range of conditions spanning neurological, muscular atrophies ...

Director Mei Fa Tan says Prince Frederik of Luxembourg "couldn't get up by himself" towards the end of his battle with PolG, a rare genetic disorder.

POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Prince Frederik of Luxembourg, son of Prince Robert and Princess Julie of Nassau, passed away at 22 in Paris due to POLG mitochondrial disease. Diagnosed at 14, Frederik advocated for research and ...

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22 ...

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.