Despite these losses, the increased delivery of potassium to the ECF from the intracellular space usually causes the serum concentration of potassium to be normal and, in some cases, high. This ...

Although the pathogenesis of DKA is better understood than that of HHS, the basic underlying mechanism for both disorders is a reduction in the net effective concentration of circulating insulin, ...

THE many changes that result from the deficiency of insulin affect all aspects of intermediary metabolism. Without the regulatory action of insulin peripheral underutilization and hepatic ...

To develop DKA, the patient must experience a relative insulin deficiency 4 (very little circulating insulin) in the setting of increased counter-regulatory hormone concentrations. This relative lack ...