Prompt eculizumab therapy may slow complement-mediated damage and improve long-term renal outcomes in pediatric lupus nephritis-associated thrombotic microangiopathy. Early eculizumab therapy may ...

Based on these postmarketing reports, the FDA is evaluating the need for further regulatory action. The Food and Drug Administration (FDA) is investigating the risk of developing neutralizing ...

Nov 21 (Reuters) - The U.S. Food and Drug Administration said on Friday it is investigating the death of a child who developed harmful antibodies after receiving Takeda Pharmaceuticals' (4502.T), ...

For reference, ADAMTS13 is a key regulator of blood clotting, preventing excessive clot formation in normal circulation. Its primary function is to cleave vWF, a large protein that helps platelets ...

The FDA said it has received postmarketing reports of neutralizing antibodies to ADAMTS13, including one death, in patients with congenital thrombotic thrombocytopenic purpura (cTTP) who were treated ...

A new mum who was diagnosed with a rare condition after spotting a "weird" bruise during pregnancy has revealed just how terrifyingly close she was to death. Rebekah, 27, was 28 weeks into her ...

Hepatic platelet accumulation in PA-ILI was confirmed in both patients and mice. Deficiency of ADAMTS13 plays a critical role in platelet accumulation in PA-ILI, suggesting that ADAMTS13 could be a ...

Pyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced liver injury ...

The COVID-19 pandemic has prompted the rapid development and administration of various vaccines worldwide, with some reports linking these vaccines to immune thrombotic thrombocytopenic purpura (TTP).

Acquired thrombotic thrombocytopenic purpura (acquired TTP, or aTTP) is a rare blood disorder that results in blood clots in small blood vessels around your body. These clots can slow the flow of ...

What Is Atypical Hemolytic Uremic Syndrome? Atypical hemolytic uremic syndrome (aHUS) is a disease that causes blood clots in small blood vessels in your kidneys and other organs. These clots keep ...