Ribosomal subunit assembly and biogenesis constitute a fundamental process vital for cellular protein synthesis across all domains of life. This complex, multi-step pathway involves the transcription ...

This study is led by Prof. Ren Sun (Westlake University) and research fellow Yushen Du (Cancer Institute, the Second Affiliated Hospital, Zhejiang University School of Medicine). Myelotoxicity is the ...

In mammalian cells, the nucleolus is the central site for ribosome biogenesis. It is composed of distinct subcompartments: the fibrillar center (FC), the dense fibrillar component (DFC), the periphery ...

MYC is a key regulator of RNA Polymerase I (Pol I) transcription, promoting rRNA synthesis both directly and indirectly. MYC overexpression is common in many cancer types, where it drives increased ...