Ubiquitin ligases regulate many processes in living cells. Depending on how many ubiquitin molecules they attach to the target proteins and in which way, they control the protein's fate. "The ...

Harvard Medical School researchers have uncovered how viruses hijack cells’ garbage-disposal systems to evade immune attack.

Small but powerful: Ubiquitin controls the lifespan and distribution of proteins in the cell, but it can also determine their shape, function, or interactions with other cellular components. Ubiquitin ...

A team of researchers led by the Walter and Eliza Hall Institute of Medical Research has produced the first systematic catalog of human E3 ubiquitin ligases, the enzymes responsible for tagging ...

Co-treatment of human GBM cell lines with imipridone ONC206 and tumor treating fields: Effect on on cell death and p-AKT. Survival implications and radiographic predictors of prognosis in patients ...

Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the ...

Impact of intratumor heterogeneity (ITH) on survival outcomes in patients with non-small cell lung cancer (NSCLC) with high tumor mutational burden (TMB-H).

July 13, 2026) Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St ...