This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the ...

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...

Transcription-coupled DNA damage repair represents a specialised branch of nucleotide excision repair that ensures rapid removal of lesions from the transcribed strand of active genes. When RNA ...

Transcription dynamics in the context of DNA damage response encompass the interactions between RNA polymerases and lesions within the DNA template, the resulting impact on transcriptional continuity, ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

Scientists at the Massachusetts Institute of Technology (MIT) have invented a new single-cell nascent RNA sequencing technique that lets them observe the timing of gene and enhancer activation in ...

Researchers have identified "DNA switches" that become active as honeybee larvae grow into worker bees, offering new insight ...

An international research team led by Forschungszentrum Jülich and the IPK Leibniz Institute has developed an artificial ...

Northwestern Medicine scientists have, for the first time, described the underlying mechanisms that regulate how cells ...

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

Researchers have identified "DNA switches" that become active as honeybee larvae grow into worker bees, offering new insight ...