Here we will look at our NFL Fantasy Football Running Back Rankings entering Week 16 of the 2025 regular season.

A lot has happened at the running back position over the first three quarters of the 2025 NFL season, so there was a lot to unpack when assembling this ranking of the league's best ball-carriers.

The NFL is all about parity, and Week 16 will offer some high-powered matchups that'll continue to create separation in several key divisions around the league.

The Seahawks are slim favorites (-1.5).