Investigators evaluated polygenic risk score (PRS) models as a risk stratification tool in Black women with an enriched family history for overall breast cancer and triple-negative breast cancer.

Genome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on the risk of human diseases, including chronic kidney disease, type 2 diabetes, ...

Polygenic risk scores (PRSs) are estimates of an individual's susceptibility to a specific complex trait obtained by aggregating the effects of dozens, thousands, and potentially millions of genetic ...

Polygenic adaptation describes evolutionary change in which many genetic variants, each of small effect, collectively shift in frequency to produce a phenotypic response to selection. Quantitative ...

Three out of four U.S. adults support the use of emerging technologies that estimate a future child's likelihood of developing health conditions influenced by multiple genes—such as diabetes, heart ...

Your risk score report tells you what percentile for a disease you’re in, a.k.a. how your risk of a given condition compares to the general population’s. For example, if you’re in the 90th percentile ...

Cancer is challenging to treat, yet identifying individuals with greater risk of developing disease can assist with early detection and increased treatment efficacy. There are several types of risk ...

“What makes the score so powerful is its ability to predict, before the age of five, whether a child is likely to develop obesity in adulthood, well before other risk factors start to shape their ...

New genetic research shows a simple genetic test can predict who’s most at risk for obesity, offering hope for early prevention, but also raises tough questions about genetic fairness and healthcare ...

The figure illustrates the major categories of genes that may influence susceptibility to dental caries, organized by their biological functions and pathways. These groups include: (1) Enamel ...

Survey reveals nearly three-quarters of U.S. adults support using emerging technology to screen embryos during IVF for risk of developing certain health conditions or traits that arise from more than ...