The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.

The San Francisco 49ers will take on the Carolina Panthers on Monday, but they'll be without two players and could have two more miss the game.

Kyle Shanahan shared why San Francisco passed on Christian McCaffrey in the 2017 draft during an interview on NBC Sports Bay Area's "49ers Game Plan."

Everything you need to know about the NFL match between 49ers and Panthers, including live streams, TV channels, kick-off time and more.

Jacksonville Jaguars wide receiver Dyami Brown could be a 2026 free-agent target for San Francisco despite his lackluster 2025 campaign. Brown has only caught 19 passes for 219 yards and one touchdown in nine games after signing a one-year deal worth $10 million with Jacksonville in March.

The San Francisco 49ers have signed kicker Matt Gay to their practice squad to replace Eddy Pineiro, and life's been hectic for Gay recently.

The 49ers re-signed QB Adrian Martinez and released RB Sincere McCormick to make room, shifting roster depth as injuries and needs changes.

The San Francisco 49ers can gain plenty of financial flexibility by releasing wide receiver Brandon Aiyuk once the 2025 season comes to a close.

Preview the Pittsburgh Steelers' NFL Week 12 matchup with the Bears, including live stream, TV channel, odds, and game information.

The San Francisco 49ers have signed kicker Matt Gay after an injury to main kicker Eddy Piñeiro Jr. Here are the details.