Figure 3: BILN 2061 concentration in human plasma after single-dose oral administration. Figure 4: Antiviral efficacy of BILN 2061 in HCV-infected patients. The antiviral results of protease inhibitor ...
To follow NS3-catalysed unwinding, we flow NS3 (1–90 nM) and ATP (0.05–1 mM) together in buffer U (see Methods). We then hold the RNA substrate at a constant force of between 5 and 17 pN. NS3 loads on ...
Thomas J. Chambers, Ronald C. Weir, Arash Grakoui, David W. McCourt, J. Fernando Bazan, Robert J. Fletterick, Charles M. Rice Proceedings of the National Academy of ...
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