MDM2 has the capacity to interact with more than 100 proteins and macromolecules and the list is continuously increasing. The explanation for how a protein of 491 aa (amino acids) is able to display ...

The p53 protein is regulated by multiple mechanisms, which is critical for its ability to respond to stress and function as a tumor suppressor. p53 turnover is regulated by MDM2, which functions as a ...

The p53–Mdm2 system is key to tumor suppression. We have recently reported that p53 as well as Mdm2 are capable of supporting DNA replication fork progression. On the other hand, we found that Mdm2 is ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 3 (Jan. 18, 2005), pp. 731-736 (6 pages) The MYCN oncogene is the major negative prognostic marker in ...

Phase II study to evaluate surufatinib in patients with osteosarcoma and soft tissue sarcoma that has failed standard chemotherapy: Updated analysis. This is an ASCO Meeting Abstract from the 2024 ...

Efficacy and safety of anlotinib combined with anthracycline and ifosfamide followed by anlotinib maintenance in advanced soft tissue sarcoma: A single-arm, phase 2 trial. This is an ASCO Meeting ...

This article and associated images are based on a poster originally authored by Sarona Jacob Anderson and presented at ELRIG Drug Discovery 2025 in affiliation with University of Salford. This poster ...