IgA nephropathy is a rare condition caused by excessive buildup of immunoglobulin A in the kidneys, slowly but progressively ...

New understanding about the pathophysiology of the condition, along with new clinical trial endpoints for approval, have ...

Vera Therapeutics recently reported a first-quarter 2026 net loss of US$121.03 million as it accelerated spending ahead of a potential U.S. commercial launch of its IgA nephropathy drug candidate ...

New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN) ...

IgA nephropathy is a progressive disease where immune proteins damage the kidneys' filtering units. Treatment options include medications and lifestyle changes to help slow progression and manage ...

Though not everyone with IgA nephropathy deals with end-stage kidney disease, around 25% of them face this complication. But there may be another option: a clinical trial. Depending on what’s ...

IgA nephropathy (IgAN) is a kidney disorder caused by a buildup of immune complexes and the antibody called immunoglobulin A (IgA) inside the kidneys. This buildup causes inflammation in the kidneys.

This transcript has been edited for clarity. Matthew A. Sparks, MD: Hi. I'm Dr Matthew Sparks. Welcome to Medscape's InDiscussion series on chronic kidney disease (CKD). Today, we'll be discussing ...

Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

To claim CE credit for this activity, please visit https://www.pharmacytimes.org/courses/preventing-progression-in-iga-nephropathy-a-managed-care-focus-on-emerging ...

Between 20 and 50 percent of individuals with IgA nephropathy will experience kidney failure within two decades of diagnosis, though the timeline varies significantly from person to person. Regular ...

MicroRNAs (miRNAs) might have important roles in the pathogenesis and progression of IgA nephropathy Abnormal expression of miR-148b in peripheral blood mononuclear cells might account for the ...