Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

The cytochrome P450 enzymes constitute a diverse superfamily of haem-containing proteins that catalyse key oxidative reactions in steroid biosynthesis. In the steroidogenic pathway, these enzymes ...

Johnson found a cytochrome P450 that converts guaiacol to catechol in a single step. To make it perform better, the team needed to understand how the enzyme works, which led to the team's efforts to ...

Alexis Garcia, PharmD, senior director of business development at Tabula Rasa HealthCare, outlines how cytochrome P450 enzymes can impact medication efficacy in patients taking multiple drugs. So the ...

Cytochrome P450 (CYP) enzymes catalyze the generation of reactive species capable of binding with cellular macromolecules, leading to acute and delayed toxicity. Since individual CYP forms differ ...

Sept. 16, 2003 — St. John's wort increases metabolism via the cytochrome P450 (CYP) enzyme system 3A4, according to the results of a study published in the Sept. 17 issue of The Journal of the ...

Cytochromes P450 are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. Suppressed drug metabolism was identified in patients with various inflammatory conditions.

In the broadest sense, immunomodulators are drugs that adjust immune responses, for example, modulation of cytokine levels. Cytokines are signaling proteins responsible for the regulation of immune ...

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express ...

Cyclin-Dependent Kinase 4/6 Inhibitor Outcomes in Patients With Advanced Breast Cancer Carrying Germline Pathogenic Variants in DNA Repair–Related Genes Our findings indicate that approximately one in ...