During mouse embryo gastrulation, epiblast cells traverse the primitive streak at the posterior end and then differentiate into mesodermal cells and migrate anteriorly. These movements are essential ...

The creation of artificial embryos has moved a step forward after an international team of researchers used mouse stem cells to produce artificial embryo-like structures capable of 'gastrulation', a ...

The study, "Selective utilization of glucose metabolism guides mammalian gastrulation," published in Nature, identifies two distinct waves of glucose utilization during mouse gastrulation. The first ...

Sozen, B. et al. Nat. Cell Biol. 20, 979–989 (2018). The ability to recapitulate early mammalian embryogenesis in a culture dish would give unprecedented access to study development and disease.

Toward the goal of generating high-quality embryo models in vitro, this study establishes a stepwise protocol to derive trophectoderm-like cells from mouse extended pluripotent stem (EPS) cells. These ...

In a recent study published in the Cell journal, researchers showed that post-gastrulation synthetic embryos (sEmbryos) could be synthesized outside the uterus using mouse naïve embryonic stem cells ...