It is well known in physics and chemistry that equal charges repel each other, while opposite charges attract. It was long assumed that this principle also applies when enzymes – the biological ...

Chemical engineers have developed an online tool that can accurately assign genes and proteins to unknown 'orphan' reactions, which are a major headache for biotechnology, drug development, and even ...

Spatiotemporal regulation of multistep enzyme reactions through compartmentalization is essential in studies that mimic natural systems such as cells and organelles. Until now, scientists have used ...

Researchers at the Manchester Institute of Biotechnology (MIB) have demonstrated how genetically engineered enzymes can harness visible light to drive highly selective chemical reactions. This ...

RFdiffusion2, RFdiffusion3, and Riff-Diff each solve different structural problems in computational enzyme design ...

Reactions that can combine more than two molecular pieces in one go are a powerful way to build complexity quickly and save on costly isolation and purification. But the choreography for such a ...

Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex ...

Natural biological systems cannot efficiently convert waste CO₂ or its derivatives into useful building-block chemicals at a scale that can keep pace with rising atmospheric carbon. Engineer a fully ...

Enzymes are proteins that facilitate biochemical reactions by acting as a catalyst, and thus, their expression and activity have a strong influence on the reactions taking place within cells. As ...