Standard genetic sequencing approaches can tell you a lot about the genetic makeup and activity in a sample, like a piece of tissue or drop of blood. But they don't tell you where specific genetic ...

According to the researcher, significant differences were found, for example, in the onset and duration of DNA replication and in the production of proteins that regulate the cell cycle. These ...

Researchers at California NanoSystems Institute at UCLA, Stockholm University and Uppsala University are working on a smartphone-based microscope in hopes of developing a cost-effective and accessible ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

Cells are the smallest units of life. But even within the same tissue or organ, they are not all identical. New variations arise continuously during cell proliferation. While genetic mutations alter ...

Transcription-replication conflicts (TRCs), especially Head-On TRCs (HO-TRCs) can introduce R-loops and DNA damage, however, the underlying mechanisms are still largely unclear. We previously ...

During replication, DNA polymerases are positioned on each strand of DNA. Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...

To exclude that enhanced lesion removal might be a consequence of damage dilution due to DNA replication, we performed an EdU-incorporation assay in L1 worms. Both lin-52 mutant and WT worms showed ...