Animal models continue to be a mainstay of basic research and preclinical studies. But since animals such as mice only approximate humans, they may generate findings of limited clinical relevance.

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Too often, preclinical successes are followed by clinical failures. And all clinical failures hurt. Perhaps the most painful failures occur in trials that require large patient populations and long ...

Tendinopathy is a common and significant clinical problem characterised by activity-related pain, focal tendon tenderness and intratendinous imaging changes. Recent histopathological studies have ...

Preclinical testing is vital for assessing the safety profiles and potential efficacy of new therapeutics in development. Animal testing is one of two routes usually selected for the preclinical stage ...

Animal testing remains to be a vital part of modern preclinical testing. While the ethics of the use of animals in medical testing remains keenly debated, it is still generally accepted worldwide and ...

New computer models predict the risk of side effects from heart drugs more accurately than animal models. Researchers from the University of Oxford (UK) have developed computer simulations that are ...

Torie Bosch is the First Opinion editor at STAT. First Opinion is STAT’s platform for interesting, illuminating, and provocative articles about the life sciences writ large, written by biotech ...

I recently read a highly-detailed, comprehensive, science-based report called The Research Modernization Deal 2021. It unambiguously shows that numerous experiments on nonhuman animals (animals) fail ...

"Rodents are the most widely utilized models in biomedical research...The majority of oncology drugs that proved successful in treating tumors within rodents fail to have the same response in humans, ...