When creating a computer program, errors in the code can introduce bugs to the software. Similarly, errors in our body's genetic code, DNA, which is stored in structures known as chromosomes, can ...

Using data from the UK Biobank, we reveal the roles of selection and mutation in shaping the genetic diversity of mosaic chromosomal alterations in healthy blood. Mosaic chromosomal alterations (mCAs) ...

Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on mutation processes that contribute to cancer and inherited genetic conditions ...

With age, hematopoietic stem cells (HSCs) accumulate somatic mutations 1. While most of these mutations have little effect on cell fitness and become simply passengers, some mutations, called drivers, ...

As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold ...

It is crucial in the development of cell and gene therapies to understand the impact of the gene editing process on chromosomal structure. When cells are edited, differentiated, modified, or ...